Gray matter correlations of cognition in incident Parkinson's disease
Identifieur interne : 002C72 ( Main/Corpus ); précédent : 002C71; suivant : 002C73Gray matter correlations of cognition in incident Parkinson's disease
Auteurs : Turi O. Dalaker ; Robert Zivadinov ; Jan P. Larsen ; Mona K. Beyer ; Jennifer L. Cox ; Guido Alves ; Kolbjorn Bronnick ; Ole-Bjorn Tysnes ; Ronald Antulov ; Michael G. Dwyer ; Dag AarslandSource :
- Movement Disorders [ 0885-3185 ] ; 2010-04-15.
English descriptors
Abstract
We aimed to investigate whether mild cognitive impairment (MCI) in Parkinson's disease (PD) is characterized by region‐specific gray matter (GM) atrophy and to explore correlations between GM and cognition in PD. Magnetic resonance images of 42 newly diagnosed PD patients (of which 11 had MCI) and 37 normal controls were analyzed using voxel‐based morphometry. Analyses comparing groups showed no regional atrophy, and in patients there were no significant correlations between cognitive domain test performance and GM loss. In conclusion, GM atrophy does not seem to be a major feature of cognitive dysfunction in incident PD. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.22867
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Dalaker</name><affiliation><mods:affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation><affiliation><mods:affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation></author><author><name sortKey="Zivadinov, Robert" sort="Zivadinov, Robert" uniqKey="Zivadinov R" first="Robert" last="Zivadinov">Robert Zivadinov</name><affiliation><mods:affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA</mods:affiliation></affiliation></author><author><name sortKey="Larsen, Jan P" sort="Larsen, Jan P" uniqKey="Larsen J" first="Jan P." last="Larsen">Jan P. 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Dalaker</name><affiliation><mods:affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation><affiliation><mods:affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation></author><author><name sortKey="Zivadinov, Robert" sort="Zivadinov, Robert" uniqKey="Zivadinov R" first="Robert" last="Zivadinov">Robert Zivadinov</name><affiliation><mods:affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA</mods:affiliation></affiliation></author><author><name sortKey="Larsen, Jan P" sort="Larsen, Jan P" uniqKey="Larsen J" first="Jan P." last="Larsen">Jan P. Larsen</name><affiliation><mods:affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</mods:affiliation></affiliation></author><author><name sortKey="Beyer, Mona K" sort="Beyer, Mona K" uniqKey="Beyer M" first="Mona K." last="Beyer">Mona K. Beyer</name><affiliation><mods:affiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation><affiliation><mods:affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation></author><author><name sortKey="Cox, Jennifer L" sort="Cox, Jennifer L" uniqKey="Cox J" first="Jennifer L." last="Cox">Jennifer L. Cox</name><affiliation><mods:affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA</mods:affiliation></affiliation></author><author><name sortKey="Alves, Guido" sort="Alves, Guido" uniqKey="Alves G" first="Guido" last="Alves">Guido Alves</name><affiliation><mods:affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation></author><author><name sortKey="Bronnick, Kolbjorn" sort="Bronnick, Kolbjorn" uniqKey="Bronnick K" first="Kolbjorn" last="Bronnick">Kolbjorn Bronnick</name><affiliation><mods:affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation></author><author><name sortKey="Tysnes, Ole Jorn" sort="Tysnes, Ole Jorn" uniqKey="Tysnes O" first="Ole-Bjorn" last="Tysnes">Ole-Bjorn Tysnes</name><affiliation><mods:affiliation>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Haukeland University Hospital, Bergen, Norway</mods:affiliation></affiliation></author><author><name sortKey="Antulov, Ronald" sort="Antulov, Ronald" uniqKey="Antulov R" first="Ronald" last="Antulov">Ronald Antulov</name><affiliation><mods:affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Radiology, Clinical Hospital Centre Rijeka, Rijeka, Croatia</mods:affiliation></affiliation></author><author><name sortKey="Dwyer, Michael G" sort="Dwyer, Michael G" uniqKey="Dwyer M" first="Michael G." last="Dwyer">Michael G. Dwyer</name><affiliation><mods:affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</mods:affiliation></affiliation></author><author><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name><affiliation><mods:affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-04-15">2010-04-15</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="629">629</biblScope><biblScope unit="page" to="633">633</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">DBF6FF96650F3C24E5371EC1814622AEE9053EE7</idno><idno type="DOI">10.1002/mds.22867</idno><idno type="ArticleID">MDS22867</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>brain atrophy</term><term>mild cognitive impairment</term><term>mri</term><term>voxel‐based morphometry</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We aimed to investigate whether mild cognitive impairment (MCI) in Parkinson's disease (PD) is characterized by region‐specific gray matter (GM) atrophy and to explore correlations between GM and cognition in PD. Magnetic resonance images of 42 newly diagnosed PD patients (of which 11 had MCI) and 37 normal controls were analyzed using voxel‐based morphometry. Analyses comparing groups showed no regional atrophy, and in patients there were no significant correlations between cognitive domain test performance and GM loss. In conclusion, GM atrophy does not seem to be a major feature of cognitive dysfunction in incident PD. © 2010 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Turi O. Dalaker MD</name><affiliations><json:string>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</json:string><json:string>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</json:string><json:string>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</json:string></affiliations></json:item><json:item><name>Robert Zivadinov MD, PhD</name><affiliations><json:string>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</json:string><json:string>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA</json:string></affiliations></json:item><json:item><name>Jan P. Larsen MD, PhD</name><affiliations><json:string>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</json:string><json:string>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</json:string><json:string>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</json:string></affiliations></json:item><json:item><name>Mona K. Beyer MD, PhD</name><affiliations><json:string>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</json:string><json:string>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</json:string></affiliations></json:item><json:item><name>Jennifer L. Cox PhD</name><affiliations><json:string>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</json:string><json:string>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA</json:string></affiliations></json:item><json:item><name>Guido Alves MD, PhD</name><affiliations><json:string>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</json:string><json:string>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</json:string></affiliations></json:item><json:item><name>Kolbjorn Bronnick PhD</name><affiliations><json:string>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</json:string></affiliations></json:item><json:item><name>Ole‐Bjorn Tysnes MD, PhD</name><affiliations><json:string>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</json:string><json:string>Department of Neurology, Haukeland University Hospital, Bergen, Norway</json:string></affiliations></json:item><json:item><name>Ronald Antulov MD</name><affiliations><json:string>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</json:string><json:string>Department of Radiology, Clinical Hospital Centre Rijeka, Rijeka, Croatia</json:string></affiliations></json:item><json:item><name>Michael G. Dwyer</name><affiliations><json:string>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</json:string></affiliations></json:item><json:item><name>Dag Aarsland MD, PhD</name><affiliations><json:string>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</json:string><json:string>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>mri</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>voxel‐based morphometry</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>brain atrophy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>mild cognitive impairment</value></json:item></subject><articleId><json:string>MDS22867</json:string></articleId><language><json:string>eng</json:string></language><abstract>We aimed to investigate whether mild cognitive impairment (MCI) in Parkinson's disease (PD) is characterized by region‐specific gray matter (GM) atrophy and to explore correlations between GM and cognition in PD. Magnetic resonance images of 42 newly diagnosed PD patients (of which 11 had MCI) and 37 normal controls were analyzed using voxel‐based morphometry. Analyses comparing groups showed no regional atrophy, and in patients there were no significant correlations between cognitive domain test performance and GM loss. In conclusion, GM atrophy does not seem to be a major feature of cognitive dysfunction in incident PD. © 2010 Movement Disorder Society</abstract><qualityIndicators><score>6.2</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>662</abstractCharCount><pdfWordCount>13414</pdfWordCount><pdfCharCount>90112</pdfCharCount><pdfPageCount>24</pdfPageCount><abstractWordCount>100</abstractWordCount></qualityIndicators><title>Gray matter correlations of cognition in incident Parkinson's disease</title><genre><json:string>article</json:string></genre><host><volume>25</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>5</total><last>633</last><first>629</first></pages><issn><json:string>0885-3185</json:string></issn><issue>5</issue><subject><json:item><value>Brief Report</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2010</publicationDate><copyrightDate>2010</copyrightDate><doi><json:string>10.1002/mds.22867</json:string></doi><id>DBF6FF96650F3C24E5371EC1814622AEE9053EE7</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/DBF6FF96650F3C24E5371EC1814622AEE9053EE7/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/DBF6FF96650F3C24E5371EC1814622AEE9053EE7/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/DBF6FF96650F3C24E5371EC1814622AEE9053EE7/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Gray matter correlations of cognition in incident Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2010</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: Nothing to report.</note><note>Dr. Larry D. Jacobs Fellowship</note><note>Research Council of Norway - No. 186966;</note><note>Norwegian Society of Radiology</note><note>Western Norway Regional Health Authority - No. 911218;</note><note>Research Council of Norway - No. 177966;</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Gray matter correlations of cognition in incident Parkinson's disease</title><author><persName><forename type="first">Turi O.</forename><surname>Dalaker</surname></persName><roleName type="degree">MD</roleName><note type="correspondence"><p>Correspondence: Department of Radiology, Stavanger University Hospital, P.O. Box 8100, N‐4068 Stavanger, Norway</p></note><affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</affiliation><affiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation></author><author><persName><forename type="first">Robert</forename><surname>Zivadinov</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</affiliation><affiliation>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA</affiliation></author><author><persName><forename type="first">Jan P.</forename><surname>Larsen</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</affiliation></author><author><persName><forename type="first">Mona K.</forename><surname>Beyer</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation></author><author><persName><forename type="first">Jennifer L.</forename><surname>Cox</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</affiliation><affiliation>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA</affiliation></author><author><persName><forename type="first">Guido</forename><surname>Alves</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</affiliation></author><author><persName><forename type="first">Kolbjorn</forename><surname>Bronnick</surname></persName><roleName type="degree">PhD</roleName><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation></author><author><persName><forename type="first">Ole‐Bjorn</forename><surname>Tysnes</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</affiliation><affiliation>Department of Neurology, Haukeland University Hospital, Bergen, Norway</affiliation></author><author><persName><forename type="first">Ronald</forename><surname>Antulov</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</affiliation><affiliation>Department of Radiology, Clinical Hospital Centre Rijeka, Rijeka, Croatia</affiliation></author><author><persName><forename type="first">Michael G.</forename><surname>Dwyer</surname></persName><affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</affiliation></author><author><persName><forename type="first">Dag</forename><surname>Aarsland</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-04-15"></date><biblScope unit="volume">25</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="629">629</biblScope><biblScope unit="page" to="633">633</biblScope></imprint></monogr><idno type="istex">DBF6FF96650F3C24E5371EC1814622AEE9053EE7</idno><idno type="DOI">10.1002/mds.22867</idno><idno type="ArticleID">MDS22867</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2010</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>We aimed to investigate whether mild cognitive impairment (MCI) in Parkinson's disease (PD) is characterized by region‐specific gray matter (GM) atrophy and to explore correlations between GM and cognition in PD. Magnetic resonance images of 42 newly diagnosed PD patients (of which 11 had MCI) and 37 normal controls were analyzed using voxel‐based morphometry. Analyses comparing groups showed no regional atrophy, and in patients there were no significant correlations between cognitive domain test performance and GM loss. In conclusion, GM atrophy does not seem to be a major feature of cognitive dysfunction in incident PD. © 2010 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>mri</term></item><item><term>voxel‐based morphometry</term></item><item><term>brain atrophy</term></item><item><term>mild cognitive impairment</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Brief Report</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-06-15">Received</change><change when="2009-10-06">Registration</change><change when="2010-04-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/DBF6FF96650F3C24E5371EC1814622AEE9053EE7/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="50"><doi origin="wiley" registered="yes">10.1002/mds.v25:5</doi><numberingGroup><numbering type="journalVolume" number="25">25</numbering><numbering type="journalIssue">5</numbering></numberingGroup><coverDate startDate="2010-04-15">15 April 2010</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="160" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.22867</doi><idGroup><id type="unit" value="MDS22867"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><titleGroup><title type="articleCategory">Brief Report</title><title type="tocHeading1">Brief Reports</title></titleGroup><copyright ownership="thirdParty">Copyright © 2010 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2009-06-15"></event><event type="manuscriptRevised" date="2009-09-09"></event><event type="manuscriptAccepted" date="2009-10-06"></event><event type="firstOnline" date="2010-03-08"></event><event type="publishedOnlineFinalForm" date="2010-04-21"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2010-03-08"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.5.2 mode:FullText" date="2011-08-12"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">629</numbering><numbering type="pageLast">633</numbering></numberingGroup><correspondenceTo>Department of Radiology, Stavanger University Hospital, P.O. Box 8100, N‐4068 Stavanger, Norway</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS22867.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="17"></count><count type="wordTotal" number="3770"></count></countGroup><titleGroup><title type="main" xml:lang="en">Gray matter correlations of cognition in incident Parkinson's disease<link href="#fn5"></link></title><title type="short" xml:lang="en">Gray Matter Atrophy and Cognition in PD</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2 #af3" corresponding="yes"><personName><givenNames>Turi O.</givenNames><familyName>Dalaker</familyName><degrees>MD</degrees></personName><contactDetails><email>datu@sus.no</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1 #af4"><personName><givenNames>Robert</givenNames><familyName>Zivadinov</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3 #af5 #af6"><personName><givenNames>Jan P.</givenNames><familyName>Larsen</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2 #af3"><personName><givenNames>Mona K.</givenNames><familyName>Beyer</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1 #af4"><personName><givenNames>Jennifer L.</givenNames><familyName>Cox</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af3 #af5"><personName><givenNames>Guido</givenNames><familyName>Alves</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Kolbjorn</givenNames><familyName>Bronnick</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af6 #af7"><personName><givenNames>Ole‐Bjorn</givenNames><familyName>Tysnes</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af1 #af8"><personName><givenNames>Ronald</givenNames><familyName>Antulov</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Michael G.</givenNames><familyName>Dwyer</familyName></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af3 #af6"><personName><givenNames>Dag</givenNames><familyName>Aarsland</familyName><degrees>MD, PhD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="NO" type="organization"><unparsedAffiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="NO" type="organization"><unparsedAffiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="NO" type="organization"><unparsedAffiliation>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="NO" type="organization"><unparsedAffiliation>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</unparsedAffiliation></affiliation><affiliation xml:id="af7" countryCode="NO" type="organization"><unparsedAffiliation>Department of Neurology, Haukeland University Hospital, Bergen, Norway</unparsedAffiliation></affiliation><affiliation xml:id="af8" countryCode="DE" type="organization"><unparsedAffiliation>Department of Radiology, Clinical Hospital Centre Rijeka, Rijeka, Croatia</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">mri</keyword><keyword xml:id="kwd3">voxel‐based morphometry</keyword><keyword xml:id="kwd4">brain atrophy</keyword><keyword xml:id="kwd5">mild cognitive impairment</keyword></keywordGroup><fundingInfo><fundingAgency>Dr. Larry D. Jacobs Fellowship</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Research Council of Norway</fundingAgency><fundingNumber>186966</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Norwegian Society of Radiology</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Western Norway Regional Health Authority</fundingAgency><fundingNumber>911218</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Research Council of Norway</fundingAgency><fundingNumber>177966</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>We aimed to investigate whether mild cognitive impairment (MCI) in Parkinson's disease (PD) is characterized by region‐specific gray matter (GM) atrophy and to explore correlations between GM and cognition in PD. Magnetic resonance images of 42 newly diagnosed PD patients (of which 11 had MCI) and 37 normal controls were analyzed using voxel‐based morphometry. Analyses comparing groups showed no regional atrophy, and in patients there were no significant correlations between cognitive domain test performance and GM loss. In conclusion, GM atrophy does not seem to be a major feature of cognitive dysfunction in incident PD. © 2010 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn5"><p>Potential conflict of interest: Nothing to report.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Gray matter correlations of cognition in incident Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Gray Matter Atrophy and Cognition in PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Gray matter correlations of cognition in incident Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Turi O.</namePart><namePart type="family">Dalaker</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</affiliation><affiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation><description>Correspondence: Department of Radiology, Stavanger University Hospital, P.O. Box 8100, N‐4068 Stavanger, Norway</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Robert</namePart><namePart type="family">Zivadinov</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</affiliation><affiliation>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jan P.</namePart><namePart type="family">Larsen</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mona K.</namePart><namePart type="family">Beyer</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jennifer L.</namePart><namePart type="family">Cox</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</affiliation><affiliation>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Guido</namePart><namePart type="family">Alves</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kolbjorn</namePart><namePart type="family">Bronnick</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ole‐Bjorn</namePart><namePart type="family">Tysnes</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</affiliation><affiliation>Department of Neurology, Haukeland University Hospital, Bergen, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ronald</namePart><namePart type="family">Antulov</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</affiliation><affiliation>Department of Radiology, Clinical Hospital Centre Rijeka, Rijeka, Croatia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael G.</namePart><namePart type="family">Dwyer</namePart><affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dag</namePart><namePart type="family">Aarsland</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2010-04-15</dateIssued><dateCaptured encoding="w3cdtf">2009-06-15</dateCaptured><dateValid encoding="w3cdtf">2009-10-06</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">2</extent><extent unit="references">17</extent><extent unit="words">3770</extent></physicalDescription><abstract lang="en">We aimed to investigate whether mild cognitive impairment (MCI) in Parkinson's disease (PD) is characterized by region‐specific gray matter (GM) atrophy and to explore correlations between GM and cognition in PD. Magnetic resonance images of 42 newly diagnosed PD patients (of which 11 had MCI) and 37 normal controls were analyzed using voxel‐based morphometry. Analyses comparing groups showed no regional atrophy, and in patients there were no significant correlations between cognitive domain test performance and GM loss. In conclusion, GM atrophy does not seem to be a major feature of cognitive dysfunction in incident PD. © 2010 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: Nothing to report.</note><note type="funding">Dr. Larry D. Jacobs Fellowship</note><note type="funding">Research Council of Norway - No. 186966; </note><note type="funding">Norwegian Society of Radiology</note><note type="funding">Western Norway Regional Health Authority - No. 911218; </note><note type="funding">Research Council of Norway - No. 177966; </note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>mri</topic><topic>voxel‐based morphometry</topic><topic>brain atrophy</topic><topic>mild cognitive impairment</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>629</start><end>633</end><total>5</total></extent></part></relatedItem><identifier type="istex">DBF6FF96650F3C24E5371EC1814622AEE9053EE7</identifier><identifier type="DOI">10.1002/mds.22867</identifier><identifier type="ArticleID">MDS22867</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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